What’s erectile dysfunction (ED)?

Erectile dysfunction is when a man has difficulty getting an erection or keeping it long enough for sex. Not only cases where erection does not occur, but also cases where erection is not enough to have satisfied sex, such as insufficient hardness and inability to get and keep erection.

Causes of ED

Sometimes erectile dysfunction only occurs in certain situations. For example, you may be able to get an erection during masturbation, or you may find that you sometimes wake up with an erection but you are unable to get an erection with your sexual partner.

If this is the case, it is likely the underlying cause of erectile dysfunction is psychological (stress related). If you are unable to get an erection under any circumstances, it is likely that the underlying cause is physical. Knowing the cause is essential for the cure.

Physical cause

Arteriosclerosis, nerve damage, narrowing of blood vessels

Erectile dysfunction is all about blood flow. To get and keep an erection, blood needs to have no problem getting to your penis. If you have erectile dysfunction, it can mean that one or more of your blood vessels have narrowed or are blocked. Plaque in your arteries, atherosclerosis, can make that happen.

Most men with erectile dysfunction have risks that make them more likely to get atherosclerosis, such as diabetes and high blood pressure.

Even in diseases such as cerebral hemorrhage and dementia that damage nerves can be the cause of erectile dysfunction since the signal of sexual stimulation captured by the brain does not reach.

Problems with blood vessel functions, including diabetes and high blood pressure

When diabetes and high blood pressure continues, blood vessels age more quickly than usual. When vessels are worn out, it does not dilate sufficiently even if there is a sexual stimulation.

Poorly controlled blood sugar levels can damage small blood vessels and nerves. Damage to the nerves that control sexual stimulation and response can impede a man’s ability to achieve an erection firm enough to have sexual intercourse. Reduced blood flow from damaged blood vessels can also contribute to erectile dysfunction.

On the other hand, even if your blood sugar is not too high, blood vessels tend to age due to other factors, such as lifestyle-related diseases, that may lead to erectile dysfunction, such as people with high blood pressure and high cholesterol, smoking and excessive drinking.

Side effects of medications

Some medications can cause erectile dysfunction regardless of age.

• Central nervous system medications: antidepressants, anxiolytics, antipsychotics
• Peripheral neuropathy medications: anesthetics, anticonvulsants
• Cardiovascular medications: diuretics, antihypertensive drug, vasodilators, cholesterol medications
• Gastrointestinal disorders medications: peptic ulcer, anticonvulsants, anticholinergic

blood vessels or nerves may be damaged due to surgery or accidents

Well-known causes of erectile dysfunction are arteriosclerosis, aging, and life-style as mentioned above, but erectile dysfunction may also be caused by an accident or surgery. Other than damage to the penis itself, damage to nerves and blood vessels can be the reasons. Spinal cord injuries and pelvic fractures, in particular, contain many fine nerves and blood vessels, so are more likely to cause erectile dysfunction.

Psychological cause

Most people in their 30s and 40s have psychological issues. Some of the most common causes of psychological impotence include the following:

• Stress
• Anxiety
• Relationship problems
• Depression
• Performance anxiety
• Guilt
• Low self-esteem

If they have anxiety and stress, it can affect the brain’s ability to send the necessary signals to trigger the desired physical response – an erection. Stress and anxiety can also contribute to an ongoing cycle of erectile dysfunction, including hormones, muscles, blood vessels, nervous system and emotions.

When thinking of depression, many think as something akin to sadness. However, depression includes frustration, loss of interest, low self-esteem, or guilt.

Treatment

Psychological counseling

If erectile dysfunction is caused by stress, anxiety or depression – or the condition is creating stress and relationship tension – your doctor might suggest to visit a psychologist or counselor. Also, relationship problems causing stress can lead to struggling in the bedroom. Communication is the first step in resolving this particular cause for psychological erectile dysfunction, but it is also one of the most difficult steps to take. If communicating with your partner is difficult, there’s always couples counseling.

Medications

Product name	Viagra	Levitra	Cialis
Common name	Sildenafil	Vardenafil	Tadalafil
Duration	< 10 hours	< 10 hours	36 hours
Time of taking to peak effect	60 minutes	30-60 minutes	60 minutes
Existence of generic	○	×	×

Treatment with medications is performed after removing lifestyle-related diseases and psychologically related factors. The three most popular erectile dysfunction treatments on the market are Viagra, Levitra and Cialis. All three treatments provide the same key benefit – better blood flow to the penis and fewer difficulties developing an erection. However, they also have some differences, ranging from duration of effectiveness to different side effect profiles.

Testosterone replacement therapy

As a man ages, the amount of testosterone in his body naturally gradually declines. This decline starts after age 30 and continues throughout life. Without adequate testosterone, a man may lose his sex drive, experience erectile dysfunction, feel depressed, have a decrease sense of well-being, and have difficulty concentrating.

Testosterone replacement therapy is effective for those with mild ED, but not moderate and severe ED.

Solving the fundamental cause

As mentioned earlier, erectile dysfunction is caused by poor blood flow. Men who have arteriosclerosis or clogged arteries in their heart often have the same problem with the arteries that supply the penis with blood. The fundamental cause of arteriosclerosis and clogged arteries is reactive oxygen species (ROS).

Erectile dysfunction is often caused by oxidative polymerization of cholesterol in blood vessels by reactive oxygen species, resulting in clogged blood vessels and poor blood flow. It is often said that cholesterol itself is bad, but when the body becomes oxidized state and the oxidized cholesterol cannot pass through the wall of blood vessel and clings to it, a blood clot occurs. In other words, in order to prevent arteriosclerosis and cholesterol oxidation, it is necessary to suppress the reactive oxygen species.

Side effects and risk of medications

Since erectile dysfunction drugs affect blood vessels in other areas of body, and not just the penis, they can be dangerous when combined with other medications or if you have certain medical conditions. You should think twice about taking erectile dysfunction drugs if you are in following situations.

You take certain medications

Nitrate, medication used to prevent chest pain, should be avoided with erectile dysfunction medications at all cost. Viagra’s side effects, for example, such as nasal congestion and headaches, are minor and unlikely to cause any health issues or significant discomfort. However, Viagra can interact with nitrates, causing serious side effects.

Usually Viagra and other erectile dysfunction medications, Cialis and Levitra, drops blood pressure by a small amount. This drop in blood pressure generally isn’t something to worry about if you’re a healthy person. However, when using Viagra with a nitrate, it can trigger a more severe drop in your blood pressure levels, which could potentially result in loss of consciousness or full-on cardiac arrest.

Even if you do not take nitrate on regular basis, if you have a heart attack during sexual activity, there is a high probability that you will be injected nitrate at a hospital. It is therefore important to inform your partner when using any of the three erectile dysfunction medications as even a healthy person may suddenly have a heart attack.

You’re at risk for heart attack or stroke

Viagra itself is not a drug that adversely affects the heart by dilating blood vessels and lowering blood pressure, but it can be dangerous to take if you have a heart disease. Patients with heart disease, such as angina, severe cardiovascular disease, and heart failure, should keep in mind that sexual activity may not be safe.

For those who have developed heart disease within the past six months are considered unsuitable for taking Viagra since it increases heart rate, blood pressure, and myocardial oxygen consumption during sexual activity. Also, caution is needed, as sexual activity itself carries cardiovascular risks.

Preventive measures

Inadequate arterial dilation results in erectile dysfunction

When sexual stimulation is transmitted from the brain to the penis via nerves, the arteries expand greatly and blood flows into the penis during normal erection. However, arteriosclerosis is a disease in which a mass of cholesterol sticks to the walls of blood vessels, causing the arteries to harden. In other words, arteriosclerosis does not let the arteries to expand, which results in less amount of blood flow for erection.

Arteriosclerosis is the cause

Arteries that become narrow and stiff prevents arteries from widening properly when tissues need more blood. Among many potential consequences, this may make it hard for the penis to get enough extra blood to produce an erection.

Arteriosclerosis not only causes erectile dysfunction, but it also causes serious diseases such as stroke and myocardial infarction. Preventing arteriosclerosis leads to preventing not only erectile dysfunction but other diseases.

Reactive oxygen species (ROS) is causing arteriosclerosis

Lifestyle habits such as lack of exercise, drinking, smoking, and bad eating habits generates ROS and oxidizes LDL cholesterol. The oxidized LDL polymerizes and hardens, forming plaque in blood vessels and accumulates in the vessel wall, which clogs arteries.

Since LDL does not oxidize unless ROS is generated, we can see how ROS is affecting our body and is the main cause of arteriosclerosis.

Solution to Erectile dysfunction

What is ROS?

When oxygen is carried into the cells of body tissues, it combines with hemoglobin in blood. While moving inside blood vessels, oxygen can be turned to ROS under stress, high level of cholesterol and disorderly oxidized vascular cells. ROS stem from several factors, including lack of exercise, unbalanced diet, stress and habitual smoking, which all develop oxidative stress that causes aging, high blood pressure, arteriosclerosis, erectile dysfunction, heart attack and stroke.

Relation between ROS and aging

When ROS damage our cells, lipids in the cell membranes is oxidized, blocking blood vessels. Once the blockage happen, oxygen cannot send nutrients to body tissues anymore, and tissue waste cannot be taken away, either. Also, as vascular cells are damaged and die, oxidized LDL cholesterol forms a firm layer inside blood vessels. This accelerates aging of blood vessels, which then develops arteriosclerosis, erectile dysfunction and other related diseases.

In this way, ROS damage and destroy cells to promote aging of the body and thus gradually cause heart attack, stroke and cancer.

Suppression on ROS can prevent erectile dysfunction

Excessive ROS in blood stack vascular cells and create blockages within blood vessels. The blockage reduce blood flow, inhibiting nutrient and energy from being supplied throughout the body.

Suppressing the ROS that causes blockage is the key to preventing erectile dysfunction.

NOMOA

-The world’s only technology that succeeded in suppressing the occurrence of ROS without medications-

NOMOA was presented as the world’s first successful study to physically suppress ROS in blood at the World Pharmaceutical Congress held in Copenhagen, Denmark in 2010. This was a joint research that had been made by Dr. Naomasa Yamamoto, Dr. Yuichi Koike, Dr. Norifumi Yonehara of Ohu University Faculty of Pharmaceutical Science, and Dr. Katsuyuki Kumano.

First, the study took blood from nine subjects and measured the level of both oxidative stress (ROS / d-ROM) and immunity (BAP) in the sampled blood. The subjects then put their index finger into the device for 10 minutes. After their blood circulated within their body once, blood was sampled to measure oxidative stress level and immunity once again. As a result, all the nine subject’s ROS levels decreased while immunity did not show any decline.

From this result, it was confirmed that NOMOA could suppress ROS in blood without affecting immunity.

To test the sleep-inducing effect on animals, we prepared a miniaturized NOMOA for mice and two mice as subjects.

First, we monitored two mice’s amount of activity with a sensor, which was activated each time the mice moved in a cage. Then, we placed one mouse in the downsized NOMOA for 10 minutes and put it back in the cage for monitoring its amount of activity. The other mouse was left untreated. The amounts of both mice were automatically recorded in the cage for 72 consecutive hours for comparison.

2.7 points was the average amount of activity per minute of the untreated mouse, whereas that of the NOMOA-affected mouse decreased by 7.6% to 48.7 points. From this result, it was demonstrated that the NOMOA-treated mouse had a longer duration of behavioral arrest than the other mouse and that NOMOA caused drowsiness and induced sleep to the mouse as NOMOA successfully suppressed its oxidative stress level (reactive oxygen level) in blood.

The testing also proved that NOMOA could suppress ROS in blood and also prevent ROS-related diseases, such as diabetes, arteriosclerosis, high blood pressure, heart attack and stroke. It also proved that NOMOA could help improving sleep disorders caused by oxidative stress.

What is high blood pressure?

Blood pressure measurement takes into account how much blood is passing through your blood vessels and the amount of resistance the blood meets while the heart is pumping.

Blood pressure is not always constant. It varies depending on the time of day when blood pressure is measured: the season, diet and stress. For example, when you are in a stressful situation, hormones temporarily increase your blood pressure by causing faster heartbeat and narrowing of blood vessels. Although tension or excitement could cause temporary increases in blood pressure, it will normally return to normal levels.

On the other hand, having a high blood pressure means your blood pressure remains high even when you are resting.

High blood pressure measurement

There are four stages of high blood pressure, and each stage has different risks.

	Systolic (mmHg)		Diastolic (mmHg)
Normal	Less than 120	and	Less than 80
Elevated	120-129	and	Less than 80
High blood pressure Stage 1	130-139	or	80-89
High blood pressure Stage 2	140 or higher	or	90 or higher
Hypertensive crisis	Higher than 180	and/or	Higher than 120

Stage 1 hypertension is a warning sign that you may get high blood pressure in the future. There is no “silver bullet” that can cure high blood pressure entirely, but changes in diet and lifestyle can improve the condition. However, when blood pressure worsens and develops into stage 2 hypertension, medication and other treatments will be required.

Symptoms of high blood pressure

Although some people with high blood pressure might have subjective symptoms, most of them do not have any, which is why it’s called “silent killer.” It is therefore dangerous to think you will hopefully have symptoms to indicate the problem developed inside you. If left unrecognized, the force of your blood pushing against the walls of your blood vessels will remain too high, which may lead to disease such as stroke and heart attack.

To prevent this from happening, it is important to measure your blood pressure regularly.

What causes high blood pressure?

Blood pressure is determined both by the amount of blood your heart pumps and the resistance of blood flow in arteries. The more blood your heart pumps and the narrower your arteries, the higher your blood pressure becomes.

High blood pressure is closely related to lifestyle as well as constitutional factors. It can be caused by a combination of factors such as excess salt, smoking, excess drinking, lack of exercise, stress and aging.

Excess salt

Taking too much salt increases the amount of sodium in the bloodstream and reduces the ability of your kidneys to remove the water. What you get is a high blood pressure due to the extra fluid and extra strain on the delicate blood vessels leading to the kidney.

Stress

When we feel stressed, our body naturally produces hormones that can temporarily increase blood pressure. Those hormones cause faster heartbeat and narrow blood vessels. The longer you feel stressed, the longer it may negatively affect your blood pressure.

Aging

As we age, increase in blood pressure is likely to be associated with structural changes in arteries, such as large-artery stiffness and thinning of blood vessels. It will limit blood flow throughout our body and increases the risk of high blood pressure. Blood vessels contract and expand with temperature, body temperature, and physical condition. However, aging disturbs the function of the autonomic nervous system, causing vascular disease.

Treatment options for high blood pressure

Lifestyle improvement

Most of the time, changes in lifestyle can significantly reduce blood pressure and lower health risks without medications. The changes include:

• Increase activity and exercise
• Control weight
• Eat well-balanced, low-sodium diet
• Limit alcohol use
• Quit smoking
• Manage stress

The above factors not only prevent high blood pressure but also reduce the risk of lifestyle-related diseases.

Medications

There are several medications to lower blood pressure.

• Thiazide diuretics: helps your body to eliminate sodium and water to reduce blood volume
• Vasodilators: opens blood vessels to allow blood to flow more easily
• Angiotensin-converting enzyme (ACE) inhibitors: helps relax blood vessels by blocking the action of natural chemical that narrows blood vessels
• Beta blockers: lower blood pressure by reducing heart rate and force of pumping
• Calcium channel blockers: relax blood vessels and reduce heart rate

What causes high blood pressure?

Low-density lipoprotein (bad cholesterol) makes blood vessels stiff and narrow

LDL cholesterol enters artery walls to cause arteriosclerosis. The heart acts as a pump to circulate blood through the network of blood vessels, but when blood vessels become stiff and narrow, the pressure cannot be absorbed resulting to high blood pressure.

If this condition continues, the blood vessel wall becomes thicker with cholesterol, so blood cannot circulate through the body, causing higher risks of stroke or heart attack.

The brain needs blood

The brain is an organ that requires a large amount of blood since it is constantly working even when we are asleep. Although the brain is only about 2% of the total body weight, it needs 15-20% of the body’s blood supply. When the vessels become thin, blood flow to the brain is limited as well, which makes brain to send signals to increase blood flow. Doing so will increase the amount of blood pumped from the heart to the entire body, which causes an increase in blood pressure.

When arteriosclerosis progresses, a small stroke may occur, resulting in loss of memory.

Complications triggered by high blood pressure

Cardiac hypertrophy

High blood pressure forces the heart to pump blood harder. To pump harder, the heart muscle becomes thick and make harder for blood to flow smoothly. It also makes it difficult for the heart to relax and pump blood sufficiently.

Cardiac hypertrophy increases the risk of other complications, such as heart failure, ventricular arrhythmias, angina, and heart attack.

Congestive heart failure

Congestive heart failure (CHF) affects the pumping power of the heart muscles. Narrowed arteries or high blood pressure makes the heart too weak or stiff to fill and pump efficiently.

Heart failure may cause symptoms, such as fatigue, shortness of breath, and swelling.

Cerebrovascular disease

About half of the cases of cerebrovascular disease are caused by atherosclerosis because of narrowing and hardening of the arteries, and high blood pressure causes or worsens arteriosclerosis. Once a stroke occurs, brain tissue dies from lack of oxygen and nutrients within an hour, leaving permanent damage on the brain.

Reactive oxygen species (ROS) is deeply involved in arteriosclerosis

High cholesterol was thought to be the only cause of arteriosclerosis that causes high blood pressure. It was thought that bad cholesterol would enter the blood vessel wall and clog the arteries. However, it has become clear that ROS in the body can also oxidize LDL cholesterol to cause arteriosclerosis.

When our body has too much LDL cholesterol, the excess fat sticks to the inside of the blood vessel walls. The fat thickens the walls and narrows blood vessels, ending up in reduction of blood flow. As the blood vessel wall becomes brittle, blood vessel itself loses elasticity and becomes stiff, leading to further progress of arteriosclerosis.

As you can see, ROS is also the main cause of arteriosclerosis.

Solution to high blood pressure

What is ROS?

When oxygen is carried into the cells of body tissues, it combines with hemoglobin in blood. While moving inside blood vessels, oxygen can be turned to ROS under stress, high level of cholesterol and disorderly oxidized vascular cells. ROS stem from several factors, including lack of exercise, unbalanced diet, stress and habitual smoking, which all develop oxidative stress that causes aging, high blood pressure, arteriosclerosis, heart attack and stroke.

Relation between ROS and aging

When ROS damage our cells, lipids in the cell membranes are oxidized, blocking blood vessels. Once the blockage happens, oxygen cannot send nutrients to body tissues anymore, and tissue waste cannot be taken away, either. Also, as vascular cells are damaged and die, oxidized LSL cholesterol forms a firm layer inside blood vessels. This accelerates aging of blood vessels, which then develops arteriosclerosis, high blood pressure and other related diseases.

In this way, ROS damage and destroy cells to promote aging of the body and thus gradually cause heart attack, stroke and cancer.

Suppression on ROS can prevent high blood pressure

Excessive ROS in blood stack vascular cells and create blockages within blood vessels. The blockage reduce blood flow, inhibiting nutrient and energy from being supplied throughout the body. As the flow is obstructed, blood pressure will rise accordingly.

The key to prevent high blood pressure is to suppress occurrence of ROS, which cause obstruction inside blood vessels.

NOMOA

-The world’s only technology that succeeded in suppressing the occurrence of ROS without medications-

NOMOA was presented as the world’s first successful study to physically suppress ROS in blood at the World Pharmaceutical Congress held in Copenhagen, Denmark in 2010. This was a joint research that had been made by Dr. Naomasa Yamamoto, Dr. Yuichi Koike, Dr. Norifumi Yonehara of Ohu University Faculty of Pharmaceutical Science, and Dr. Katsuyuki Kumano.

First, the study took blood from nine subjects and measured the level of both oxidative stress (ROS / d-ROM) and immunity (BAP) in the sampled blood. The subjects then put their index finger into the device for 10 minutes. After their blood circulated within their body once, blood was sampled to measure oxidative stress level and immunity once again. As a result, all the nine subject’s ROS levels decreased while immunity did not show any decline.

From this result, it was confirmed that NOMOA could suppress ROS in blood without affecting immunity.

To test the sleep-inducing effect on animals, we prepared a miniaturized NOMOA for mice and two mice as subjects.

First, we monitored two mice’s amount of activity with a sensor, which was activated each time the mice moved in a cage. Then, we placed one mouse in the downsized NOMOA for 10 minutes and put it back in the cage for monitoring its amount of activity. The other mouse was left untreated. The amounts of both mice were automatically recorded in the cage for 72 consecutive hours for comparison.

2.7 points were the average amount of activity per minute of the untreated mouse, whereas that of the NOMOA-affected mouse decreased by 7.6% to 48.7 points. From this result, it was demonstrated that the NOMOA-treated mouse had a longer duration of behavioral arrest than the other mouse and that NOMOA caused drowsiness and induced sleep to the mouse as NOMOA successfully suppressed its oxidative stress level (reactive oxygen level) in blood.

The testing also proved that NOMOA could suppress ROS in blood and also prevent ROS-related diseases, such as diabetes, arteriosclerosis, high blood pressure, heart attack and stroke. It also proved that NOMOA could help improve sleep disorders caused by oxidative stress.

What is diabetes?

Diabetes is caused when insulin isn’t made enough, or any, by the pancreas. When insulin isn’t made enough, we cannot control blood sugar.

There are two main types of diabetes: Type 1 patients need to take insulin every day to stay alive, and type 2 that is caused by insulin resistance, a condition in which the body’s cells cannot use insulin as efficiently as normal.

Type 2 diabetes

90% of patients who develop diabetes have this type 2 diabetes. Type 2 diabetes is a disease in which the amount of glucose in the blood becomes higher than normal due to insufficient secretion of insulin in the pancreas. In the past, most of the cases occurred after the age of 40, but diabetes diagnoses among youth are becoming more common because of the high proportion of fat in our diet.

Due to high-calorie and / or high-fat diet, lack of exercise, and constitution, insulin secretion by the pancreas decreases. Insulin, which is made by the pancreas, originally works to lower blood glucose (blood sugar) levels, but in type 2 diabetes, insulin secretion is insufficient, making it impossible to control blood glucose levels.

Type 2 diabetes can be controlled with lifestyle, such as healthy eating and exercising, and taking insulin when insulin is either insufficient or ineffective. However, if you cannot control your blood sugar level with your medication, you will need insulin injections.

Type 1 diabetes

Type 1 diabetes usually appears before the age of 40, and accounts for 10% of all people with diabetes. While type 2 diabetes can be controlled with improving lifestyle, type 1 diabetes has nothing to do with diet or lifestyle.

When you have type 1 diabetes, you cannot produce any insulin, so insulin injection will be unavoidable. Without insulin, your body will break down its own fat and muscle, leading to a serious condition called diabetic ketoacidosis. If left untreated, people die quickly, so you need to rely on insulin injection for survival.

When you don’t manage your diabetes and control your blood sugar, complications occur. Some of the common complications are: kidney disease, heart disease, stroke, eye disease, and high blood pressure. It is important to take insulin regularly to control blood sugar.

The cause of diabetes

What is blood sugar?

Blood sugar comes from the food you eat. Your body creates blood sugar by digesting some food into a glucose that circulated in your bloodstream. Most of the digested food is then absorbed by the small intestine to be used as energy, and the excess glucose will be converted to fat. The key to this process is insulin.

How insulin works

Insulin is released from your pancreas and plays a role in sending glucose in your bloodstream. The pancreas detects the rise in blood glucose and starts to secrete insulin. Insulin works by improving the uptake of glucose from the blood into the cells of body, and takes glucose out of the bloodstream. Once the glucose is used as the energy to fuel the cells, glucose level drops.

What happens when your insulin levels drop?

When insulin, which plays an important role in delivering glucose to cells, is not sufficiently secreted or fails to function properly, the body can no longer move glucose from the blood into the cells, causing high blood glucose levels. When the glucose level is too high, excess glucose will be removed from the body along with urine.

Type 2 diabetes can be caused when the available insulin doesn’t work properly. Even though insulin is secreted, the action is impaired.

On the other hand, type 1 diabetes produce very little or no insulin at all. When impaired insulin secretion, glucose will not be delivered to cells and remains in the bloodstream, resulting in hyperglycemia.

When the blood sugar becomes too high, the pancreas tries hard to make insulin, but the pancreas itself weakens and gradually becomes tired. Then, amount of insulin decreases, resulting in an increase in blood sugar.

Early signs and symptoms of diabetes

Type 2 diabetes often has almost no subjective symptoms at the early stage, and most people cannot notice it. However, it is said to occur easily in the following people:

• 40 years or older
• Overweight
• Family member has diabetes
• Lack of exercise

Also, if you are aware of the following symptoms, which are often listed as the initial symptoms, it is highly possible that the condition has already progressed to some extent.

• Feeling very tired
• Frequent urination
• Increased thirst and hunger
• Blurry vision
• Slow healing of wounds
• Numbness or pain in the hand or feet
• Itching and yeast infections
• Sexual function problem

Diabetes are often pointed out by blood tests, so having a health checkups can be an effective preventive measure.

Diabetes prevention

When it comes to type 2 diabetes, prevention is very important. Nearly one-third of adults are at risk of developing type 2 diabetes, so try to improve your lifestyle before you have them. Prevention listed often are as basic as eating healthier, becoming more physically active and losing a few pounds. Except for the above-mentioned measures against diabetes, managing blood pressure and controlling blood sugar level is important.

Manage blood pressure

High blood pressure causes poor blood flow, which causes the heart and the brain from getting enough oxygen and nutrients to function properly. If there is ROS, oxidative stress increases, inflammation in blood vessels occurs, and the function of the pancreas reduces.

Even when blood pressure is very high, it often causes no symptoms at all and that’s why people may live with it unknowingly for a long time. It is important to maintain proper weight and reduce salt intake at the same time.

Control blood sugar

When the function of the pancreas decrease, the amount of insulin production becomes insufficient. Also, obesity due to overeating and lack of exercise interferes with insulin. When the resulting hyperglycemia continues, the risk of heart disease and stroke increases by 2 to 4 times. It is necessary to control the blood sugar level to prevent complications.

Risk of developing diabetes

Complications of diabetes

If blood sugar levels are continued to be very high, it can cause problems with other body functions. The longer you have diabetes, the higher the risk of complications. Eventually, diabetes complications may be disabling or even life-threatening. Possible complications include:

• Eye damage (retinopathy)

The retina is a thin lining on the back of the eye, and when high blood sugar is kept from diabetes, blood flow becomes poor. You may not have any signs at first, but as it worsens, blood vessels weaken and leak blood and fluid. This causes blocks in your vision and may cause blindness.

• Kidney damage (nephropathy)

Diabetic nephropathy affects your kidneys’ ability to remove waste from your body. Severe damage can lead to kidney failure or irreversible end-stage kidney disease, which may require dialysis or kidney transplant. If you start to have dialysis treatments for your whole life unless you are able to get a kidney transplant.

• Nerve damage (neuropathy)

Long-term hyperglycemia are critical for peripheral nerve damage, resulting in excessive sweating, irregular bowel movements, and erectile dysfunction in men may also occur. If left untreated, the damage caused by neuropathy can potentially lead to infection and limb amputation.

• Cardiovascular disease

People with diabetes are three times more likely to have heart attack or stroke than people without it. Both strokes and heart attacks can occur due to blocked arteries. Over time, high blood glucose from diabetes can damage your blood vessels and the nerves that control both your heart and blood vessels. Atherosclerosis clogs your arteries blocking nutrients to reach the cells. The cells in brain and heart cannot be repaired or regenerate, which causes serious sequelae. Depending on where it occurs, heart attack deaths occur within 10 minutes, and stroke can cause weakness or paralysis on one side of the body, or worse, the whole body.

What is the cause of insulin deficiency?

At an early stage, it is possible to get your blood glucose level back to normal range with lifestyle modifications such as eating a healthier diet, exercising more, or reduce the amount of insulin by taking oral pills that increase the release of insulin from the pancreas.

However, type 1 diabetes cannot make insulin, so they must inject insulin to control their blood glucose levels.

Lack of insulin in the body, cells can no longer take up glucose from the blood, and the blood glucose level increases. Poor glycemic control declines renal function, leading to rental failure. Patients with stage 3 chronic kidney disease will undergo dialysis treatments in about two years, and heart attack is the most common cause of death among people on dialysis. On average, life expectancy after initiation of dialysis is approximately eight years.

The root cause is ROS (reactive oxygen species), which reduces insulin secretion by the pancreas.

Solution to Diabetes

What is ROS (reactive oxygen species)?

Oxygen taken in by the body combines with hemoglobin in the blood and is carried to cells in each tissue of the body. While moving in the blood, oxygen becomes ROS due to the effects of stress, disorderly oxidized surrounding cells and cholesterol. ROS is generated in the blood due to lack of exercise, unbalanced diet, stress, and smoking, and those generate oxidative stress that causes aging, high blood pressure, arteriosclerosis, heart attack, and stroke.

Relationship between ROS and aging

When cells are attacked by ROS, lipids in the cell membranes of blood vessels are oxidized, blocking the blood vessels. When a blockage of the blood vessels happen, nutrients cannot be sent to the body tissues, and tissue waste cannot be taken away. Also, damage to vascular cells lead to death of vascular cells and oxidation of LDL cholesterol in the blood to form a hard layer inside blood vessels. This accelerates aging of blood vessels as arteriosclerosis and high blood pressure.

In this way, ROS damages or destroys cells, which promotes aging of the entire body and gradually causes heart attack, stroke, or cancer.

Suppressing ROS can prevent type 2 diabetes

When excessive amount of ROS is generated in the blood, it attacks the cells of blood vessels, blocks blood flow, which causes blockage inside. The blockage reduces blood flow, reducing nutrients and energy being supplied to the entire body. ROS also affects the pancreatic function that secretes insulin.

The beta cells in the pancreas secrete insulin, but since these beta cells are very weak to ROS, if the ROS is supplied to the pancreas by the blood, the vitality of beta cells will be lost and the amount of insulin secretion will decrease resulting in high blood sugar.

As described, diabetes and ROS are closely related, and suppression of ROS is the key to improving diabetes by activating the function of the pancreas without any control of insulin.

Diabetes can be prevented by suppressing ROS, which results in preventing arteriosclerosis and blockage, and improving the vitality of cells of the pancreas to normalize insulin secretion.

NOMOA

-The world’s only technology that succeeded in suppressing the occurrence of ROS without medications-

In 2010, NOMOA was announced as the world’s first successful study to physically suppress ROS in the blood at the World Pharmaceutical Congress held in Copenhagen, Denmark. This was a result of a joint research by Dr. Yamamoto, Dr. Koike, Dr. Yonehara of the Faculty of Pharmaceutical Science of Ohu University in Fukushima, Japan, and Dr. Kumano.

This study first took nine volunteers’ blood and measured the level of oxidative stress (ROS / dROM) and immunity (BAP) in the blood. Then, they put their index finger into the device for 10 minutes. After the blood circulation, it was sampled again to measure both oxidative stress level and immunity. As the result, it was confirmed that all nine volunteers’ level of ROS decreased, and immunity (BAP) did not show any decline.

From this, it was confirmed that the NOMOA suppressed ROS in the blood, and that it had no effect on immunity.

To test the effects of sleep-inducing effects on animals, we have prepared NOMOA that can fit the whole body of a mouse.

First, we measured the amount of activity with a sensor, which was activated each time the mouse moved in the cage. Then, the mouse was placed in NOMOA for 10 minutes and put back in the cage and measured the amount of activity. The test was automatically measured for each two mice for 23 hours.

The average amount of activity per minute of the mouse was 52.7 point, whereas the amount of activity of the NOMOA-affected mouse was 48.7 points per minute on average, which was decreased by 7.6%. From this, it was demonstrated that the NOMOA-treated mice had a longer duration of behavioral arrest. This can be said to have caused drowsiness in mice and induced sleep when the oxidative stress level (active oxygen level) in blood is suppressed.

It is also proved that the action of NOMOA suppresses ROS in the blood and prevents disease caused by ROS, such as diabetes, arteriosclerosis, high blood pressure, heart attack, and stroke. Also, it helps to eliminate sleep disorders caused by oxidative stress.

In July 2018, we have presented the world’s first research to lower blood pressure physically without using any medications with wrist-type NOMOA at the World Congress of Basic and Clinical Pharmacology in Japan. In the test, a control, magnet, and NOMOA were worn in turns for 24 hours on 19 volunteers with a blood pressure meter that is capable to measure continuously for 24 hours.

The blood pressure of all 19 NOMOA-treated volunteers decreased by an average of about 5 mmHg compared to the controls and magnets.

From the results from both studies, it was proved that the use of NOMOA can suppress ROS, which causes diabetes, and also lower blood pressure.

Oxidative stress and reactive oxygen species

When we breathe, we take in oxygen into our bodies to produce energy to run our bodies. Part of the oxygen we take in is converted into a substance called reactive oxygen species. Many people have likely heard that an increase in reactive oxygen species is harmful to the body. Reactive oxygen species (ROS) have been attracting attention as a cause of many lifestyle-related diseases, from aging phenomena such as blotches and wrinkles on the skin to arteriosclerosis and cancer.

Reactive oxygen species (ROS) are oxygen species that have a very strong ability to oxidize other substances, but they do not only do bad things. They also play an important role in fighting off bacteria and viruses that invade the body. However, if the amount of reactive oxygen species increases too much, it can also attack normal cells and genes.

Reactive oxygen species and diseases

The main diseases in which reactive oxygen species are involved include arteriosclerosis, myocardial infarction, cerebral infarction, cancer, diabetes, and Alzheimer’s disease.

Reactive oxygen species are carried throughout the body by the blood. Therefore, they oxidize and destroy every organ in the body, causing diseases. It is said that as many as 90% of all diseases are triggered by reactive oxygen species. Cancer, heart disease, cerebral infarction, etc. have different parts affected, and at first glance it may seem that there is no connection between them, but they all have something in common: reactive oxygen species are deeply involved.

Of course, not everyone gets sick due to reactive oxygen species, but people with weak antioxidant capacity are more likely to get sick.

Reactive oxygen species and aging

There are so many theories about the causes of aging, but when we trace the root cause, we arrive at reactive oxygen species. The aging process occurs when the cells and tissues of the body, such as blood vessels, muscles, bones, and brain, are oxidized by reactive oxygen species and their functions deteriorate. The term “active” in reactive oxygen species means that they are easily reactive, and they immediately react with the lipids in the cells and change into a substance called lipid peroxide. This is the rust of the body. Lipid peroxides cause oxidative reactions at random, damaging cell membranes and leading to lifestyle-related diseases and aging.

In order to protect ourselves from the attacks of reactive oxygen species, our bodies are equipped with antioxidant power. However, it is said that the ability to scavenge reactive oxygen species peaks at the age of 20, after which it gradually declines, and by the time we reach our 40s, the negative effects of reactive oxygen species start to become noticeable. To compensate for the decline in antioxidant capacity, we need to make efforts not to increase the amount of active oxygen.

It is generally said that moderate exercise, taking in foods with high antioxidant power, eliminating lack of sleep and stress, and quitting smoking and excessive drinking are good ways to do this, but they need to be continued for one to two months for the effects to appear. In contrast, a revolutionary method has been discovered that reduces oxidative stress levels in the blood and does not lower the immune system by simply placing your fingers in the device for just 10 minutes.

NOMOA

– Inhibits the generation of reactive oxygen species in the blood without the use of drugs-

Reduces the level of reactive oxygen species in the blood

In 2010, at the World Congress of Clinical Pharmacology held in Copenhagen, Denmark, the world’s first study that succeeded in physically suppressing reactive oxygen species in the blood was presented.

In this study, blood samples were first taken from nine subjects, and the degree of oxidative stress (reactive oxygen species) in the blood (DROM) was measured, while at the same time BAP, which indicates immunity, was measured. After that, the index finger was inserted into the device for 10 minutes, and after the blood had circulated, the finger was removed, and the blood of all the subjects was taken again to measure the oxidative stress level and immunity. As a result, it was confirmed that the level of active oxygen decreased in all nine subjects. In all nine subjects, the level of reactive oxygen species (ROS) decreased, and immunity (BAP) did not decrease at all.

In other words, NOMOA reduced only the level of reactive oxygen species without lowering immunity.

Improvement of sleep disorders

We also prepared a NOMOA device that could hold the entire body of a mouse and tested the effects of sleep induction on the animal.

First, we put the mice in a cage and measured their behavior. Next, we prepared a NOMOA device that could hold the entire body of a mouse, and after letting it work for 10 minutes, we returned the mouse to its cage and measured its behavior again. We automatically measured this test for 23 hours for two mice each.

The average amount of behavior by sensor operating points per minute for mice that had not been exposed to NOMOA was 52.7 points, whereas the amount of behavior for mice that had been exposed to NOMOA was 48.7 points per minute on average, a 7.6% decrease. This demonstrated that the duration of behavioral cessation was prolonged in mice treated with NOMOA.

It can be said that NOMOA induced drowsiness in the mice, as there are references that suppressing the oxidative stress level (amount of reactive oxygen species) in the blood induces sleep.

It has been proven that NOMOA suppresses reactive oxygen species (ROS) in the blood and prevents diseases such as diabetes, arteriosclerosis, hypertension, and myocardial infarction caused by ROS, as well as eliminating sleep disorders caused by oxidative stress.

Improvement of high blood pressure

In 2018, the world’s first research presentation on physically lowering blood pressure without using drugs was made at the the International Society of Clinical Pharmacology, held in Kyoto, Japan. The ankle-worn version of the NOMOA was used at that time.

In the study, 19 subjects wore the control, the magnet, and the NOMOA in that order for 24 hours, and then wore a blood pressure monitor on their bodies that could measure blood pressure continuously for 24 hours.

When the subjects wore the control, their blood pressure did not change, and when they wore the magnet device, their blood pressure increased, but when they wore the NOMOA, their blood pressure decreased by an average of about 5 mmHg.

From these research results, it was proven that the use of NOMOA can reduce blood pressure and suppress active oxygen, which causes diseases such as diabetes, hypertension, and thrombosis, as well as aging.

What is thrombosis?

Cancer, heart disease, and cerebrovascular disease are the world’s leading causes of death. Of these, myocardial infarction accounts for 90% of cardiovascular diseases, and cerebral infarction, which accounts for the majority of cerebrovascular diseases, is caused by thrombosis, in which a blood clot forms in a blood vessel and stops blood flow.

Thrombosis is characterized by a sudden onset, the possibility of residual functional impairment, and the possibility of recurrence. Thrombosis often occurs suddenly and is asymptomatic until one second before the onset. The scary thing about thrombosis is that a seemingly healthy person can become seriously ill in an instant. In addition, paralysis may remain after the onset of the disease even if it is treated, and it may recur even after treatment.

Thrombosis can be triggered by lifestyle disorders such as smoking, eating and drinking too much fatty food, lack of sleep, lack of exercise, and stress, as well as blood contamination and stagnation caused by active oxygen.

It is important to prevent thrombosis before it occurs.

Thrombosis classification

Arterial thrombosis

Arterial thrombosis is a thrombosis in an environment with rapid blood flow. Cerebral infarction and myocardial infarction are typical examples of this disease. When blood flow is fast, platelets are easily activated and a thrombus with a high platelet content (platelet thrombus) is formed.

Venous thrombosis

Venous thrombosis is a thrombosis in an environment with slow blood flow. Typical examples are deep vein thrombosis and cerebral infarction caused by atrial fibrillation. When blood flow is slow, coagulation is easily activated and a clot (coagulated thrombus) with a high content of fibrin (the end product of coagulation activation) is formed.

Causes and characteristics

Obstruction of blood flow

Blood stagnation and thrombosis occur when there is an obstruction to blood flow. For example, working at a desk, flying for a long time, watching movies for a long time, or resting for a long time after surgery or childbirth can cause blood flow to stagnate. This is when the role of the lower limbs becomes important.

In the first place, blood flow in the lower part of the body is controlled by the contraction of the large muscles in the calves and thighs, which act like a pump, carrying the blood flow in the lower limbs to the heart and allowing blood to circulate throughout the body. However, if the lower part of the body is immobile due to prolonged sitting, the pumping function of the muscles does not work, and blood clots can form in the lower limbs.

Blood clots form easily

Blood clots are also formed when the blood clots and becomes difficult to flow. This is especially common in chronic diseases such as hyperlipidemia and diabetes. Once the blood starts to clot, a significant number of blood clots in a matter of seconds. Blood that encounters the clot will form another clot, and then blood will hit the newly formed clot and form another clot, and so on, creating a chain of events in which blood flowing one after another form clots. If the clot completely blocks the blood vessel and blood cannot flow, the tissue that has lost its blood supply will die. This is known as an infarction.

Arrhythmia

Most arrhythmias are harmless, but they can be dangerous if you suddenly lose consciousness, feel dizzy when you move your body, or if your heart suddenly starts palpitating. Atrial fibrillation is one of the most common arrhythmias that can occur in old age and can cause very strong palpitations. Atrial fibrillation does not kill you immediately, but if the condition persists, blood clots (thrombus) can easily form in the atria. If the blood clot gets stuck in a blood vessel in the brain, a stroke will occur. In addition, since the heart is always running at full speed, if this condition persists for a long time, the heart muscle will weaken, increasing the possibility of heart failure.

Arteriosclerosis

Atherosclerosis is a condition in which blood vessels lose their suppleness and harden as they age, and cholesterol- and lipid-laden blood adheres to the vessels, causing them to become thinner and the flow of blood to become sluggish. In healthy blood vessels, blood flows without stagnation, but when arteriosclerosis causes blood flow to stagnate in a blood vessel, blood tends to clot there, forming a blood clot. A cerebral infarction or myocardial infarction occurs when a blood clot formed in a blood vessel of the brain or a blood clot carried from the heart obstructs the blood vessel.

Initial symptoms

You may have an image that cerebral infarction and myocardial infarction occur suddenly, but there are signs. For example, in the case of cerebral infarction, the symptoms of a transient ischemic attack will subside in a few minutes at the shortest or 30 minutes at the longest. Typical examples of transient ischemic attacks are aphasia, which is a sudden loss of speech, and speech disturbance, which is a loss of speech. Other symptoms that may appear without any cause are as follows:

– Sharp chest pain, sudden shortness of breath

– Crushing pain in the chest

– Severe headache, dizziness, fainting, visual or speech disturbances

– Weakness or paralysis of one limb on either side

– Loss of vision on one side

– Facial paralysis on one side

The initial symptoms are caused by a temporary clogging of blood vessels by a blood clot, and since the clot is not completely blocked, the symptoms will go away in a few minutes. Even if the symptoms are only temporary, it is possible that the blood vessels are becoming more easily clogged, and in such cases, it is advisable to seek medical attention.

Improvement and prevention measures

Cholesterol, blood pressure, and blood sugar management

High cholesterol can block blood vessels and reduce blood flow, which can lead to myocardial infarction and stroke. The risk of heart disease and stroke is more than four times higher in people with diabetes than in those without.

One of the major causes of thrombosis is arteriosclerosis. Hypertension, hyperlipidemia, diabetes, and heart diseases such as atrial fibrillation are some of the conditions that promote this arteriosclerosis and damage blood vessels. The causes of these diseases are smoking, drinking, obesity, and other lifestyle disorders. There are risk factors lurking in our daily lives. Since atherosclerosis has no subjective symptoms, it is important to reduce bad cholesterol and strengthen the elasticity of blood vessels by taking care to improve diet and lack of exercise on a daily basis.

Reactive oxygen species are deeply involved in atherosclerosis

It has been said that atherosclerosis, which is believed to cause thrombosis, is only caused by excessive intake of cholesterol. It has been thought that the bad cholesterol enters the blood vessel wall and causes the vessel to become blocked and clogged, but in fact, the bad cholesterol is oxidized by the reactive oxygen species generated in the body, and the hard bad cholesterol oxidized and hardened by the oxidation is the cause of atherosclerosis.

The volume of the bad cholesterol oxidized and oxidized and hardened by the active oxygen swells up, lifts up the inner membrane of the blood vessel, and narrows the inside of the vessel. The blood vessel wall in that area becomes brittle, and the blood vessel itself loses its elasticity and becomes stiff. In this way, arteriosclerosis progresses.

In this way, we can see how active oxygen corrodes blood vessels, and that active oxygen is the main cause of arteriosclerosis.

Solution

About reactive oxygen species

Oxygen taken into the body through respiration combines with hemoglobin in the blood and is transported to the cells of each tissue in the body. The oxygen that leaves the hemoglobin due to stress or other factors while traveling through the blood vessels becomes reactive oxygen species, which oxidize the surrounding cells and cholesterol in a disorderly manner. Excessive lack of exercise, unbalanced diet, stress, smoking, etc. can produce reactive oxygen species in the blood, and the resulting oxidative stress can cause aging and aging-related high blood pressure, arteriosclerosis, myocardial infarction, and cerebral infarction.

Relationship between reactive oxygen species and aging

When cells are attacked by reactive oxygen species, the lipids in the cell membranes of blood vessels oxidize, blocking blood vessels and preventing the smooth flow of nutrients and waste products between the blood and cells in the vessels. In addition, when blood vessel cells are damaged and die, or when LDL cholesterol in the blood oxidizes and forms a hard layer inside the blood vessels, it accelerates the aging of blood vessels as arteriosclerosis and hypertension. In this way, reactive oxygen species (ROS) can damage or destroy cells, thus accelerating the aging of the entire body and gradually becoming the cause of myocardial infarction, stroke, or cancer.

Inhibition of reactive oxygen species prevents thrombosis

When excessive amounts of reactive oxygen species are generated in the blood, oxidation is more likely to occur and the LDL cholesterol in the blood turns into oxidized LDL. This oxidized LDL cholesterol becomes hard LDL cholesterol oxidized and hardened by oxidation and accumulates in the inner membrane of blood vessels. The accumulated oxidized LDL lifts up the intima of the blood vessel and causes blockage in the blood vessel. Arteriosclerosis is when the blood vessels lose their elasticity and become stiff.

Since LDL cholesterol does not oxidize unless active oxygen is generated in the first place, suppression of active oxygen is important.

NOMOA　

-The world’s only drug-free method to physically suppress the generation of reactive oxygen species in the blood-

In 2010, at the World Congress of Clinical Pharmacology held in Copenhagen, Denmark, the world’s first successful study on the physical inhibition of reactive oxygen species in the blood was presented. This research was the result of a collaboration between Dr. Kumano and Dr. Yamamoto, Dr. Koike, and Dr. Yonehara of the School of Pharmaceutical Sciences at Ohu University in Koriyama, Fukushima Prefecture, Japan.

The study began by taking blood samples from nine subjects and measuring the level of oxidative stress (reactive oxygen species) in their blood (DROM), as well as measuring their BAP, which indicates their immunity. Then, the index finger was inserted into the device for 10 minutes, and after the blood had circulated, the finger was removed and the blood of all the subjects was taken again to measure the oxidative stress level and immunity. As a result, it was confirmed that the level of reactive oxygen species (ROS) decreased in all nine subjects. However, there was no decrease in immunity (BAP).

This confirmed that NOMOA suppressed ROS in the blood and had no adverse effect on immunity.

In order to test the effects of sleep induction on animals, we prepared a NOMOA device in which the entire body of a mouse could fit.

At first, in a control state, the sensor was activated whenever the mouse moved in the cage, and the amount of movement was measured. Next, after letting NOMOA work for 10 minutes, we put the mice in the cage, activated the sensor whenever they moved, and measured the amount of behavior. We automatically measured the above tests for 23 hours for two mice each.

While the control mice averaged 52.7 sensor operating points per minute, the NOMOA-activated mice averaged 48.7 points per minute, a 7.6% decrease. This demonstrated that the periods of inactivity was prolonged in the NOMOA-treated mice. It can be said that NOMOA induced sleepiness in the mice, as there are references that suggest that suppressing oxidative stress levels (amount of reactive oxygen species) in the blood induces sleep, and the effect of NOMOA is to suppress reactive oxygen species in the blood and prevent diabetes, arteriosclerosis, hypertension, and myocardial infarction caused by reactive oxygen species. In addition, it has been proven that NOMOA can help eliminate sleep disorders caused by oxidative stress.

In July 2018, Ohu University and Dr. Kumano jointly presented the world’s first research on physically lowering blood pressure using NOMOA without using drugs at the International Society for Clinical Pharmacology in Kyoto, Japan. The ankle-worn type of NOMOA was used at that time. In the test, 19 subjects wore the control device, magnet device, and NOMOA in that order for 24 hours, and then wore a blood pressure monitor on their bodies that could measure blood pressure continuously for 24 hours. The blood pressure of all 19 subjects wearing the NOMOA decreased by an average of about 5 mmHg compared to the control device and the magnetic device. There was no change in the blood pressure of all subjects wearing the control device. All of the subjects who wore the magnetic device showed an increase in blood pressure.

From these research results, it has been proven that the use of NOMOA can inhibit reactive oxygen species that cause thrombosis and lower blood pressure.